Hex Fiend
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Iām impressed: Hex Fiend instantly opened an 8.5 gigabyte file I needed to extract some data from. No trouble searching for the starting bytes, no slowdown selecting or deleting multi-gigabyte section, no problem saving the multi-gigabyte result. Yes, this is on a machine with lots of RAM, but even here Iām used to apps choking on files this size. Even BBEdit gets slow when you hand it something that big.
More info at Hex Fiend.
Available from Hex Fiend (Installer), GitHub (Source), App Store (Old).