Category: Pandemic Diary

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Last Friday, I dropped off my ballot for today’s primary election. I’ve got to say, I really appreciate the new approach in LA County of mailing everyone eligible a ballot, maintaining permanent drop boxes at relevant locations (libraries, etc.), and opening some polling places early to accept completed ballots.

MUCH more convenient than needing the time on one specific day and, in elections with a lot of turnout, waiting 45 minutes, an hour, or longer.

The longest I’ve waited was when I was living in Orange County, either 2003 or 2004, and they actually had to apply the “if you’re in line at closing time, you get to vote” rule. Someone brought a box of to-go coffee from the Starbucks down the street (I think Starbucks might have donated it, too?) and was offering it either to the poll workers or to those of us still in line.

The first election in which the county implemented early voting and flexible polling places (instead of requiring you to get to the specific place on your sample ballot) was also the week before COVID-19 hit the area. Now that I think of it, they still didn’t send out an actual ballot by mail unless you requested one. That changed when it became clear COVID wasn’t going to just blow over before November. Since then some of the smaller, local elections have been mail-only.

Four years….WTF

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This is fascinating: Researchers looked at variations in the human leukocyte antigen (HLA) genes of people who had confirmed cases of Covid before the vaccine rollout and also had genetic records on file.

Those with a particular variation were twice as likely to have been asymptomatic.

Having that same variation from both parents made them 8.5 times as likely to have been asymptomatic!

They looked at two more cohorts and found the same results.

And then they looked at T-cells collected before the pandemic, and found that the ones with this allele responded more actively to SARS-COV2, despite never having been exposed to it before. That lends weight to the hypothesis that some people’s immune systems were able to recognize it as similar to more run-of-the-mill coronaviruses.

Next they want to broaden the study more to include people with a wider range of ancestry.

It doesn’t come close to explaining all asymptomatic cases, and they didn’t look at how it might stack with immune responses that are actually targeted at covid (vaccines, prior infections), or whether it also reduces the chances of long-term damage from covid.

But wouldn’t it be great if someone could come up with a supplement based on what this HLA variant produces that’ll cause your immune system to generalize better? Even if it’s just within coronaviruses?