Tag: Covid-19

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This is fascinating: Researchers looked at variations in the human leukocyte antigen (HLA) genes of people who had confirmed cases of Covid before the vaccine rollout and also had genetic records on file.

Those with a particular variation were twice as likely to have been asymptomatic.

Having that same variation from both parents made them 8.5 times as likely to have been asymptomatic!

They looked at two more cohorts and found the same results.

And then they looked at T-cells collected before the pandemic, and found that the ones with this allele responded more actively to SARS-COV2, despite never having been exposed to it before. That lends weight to the hypothesis that some people’s immune systems were able to recognize it as similar to more run-of-the-mill coronaviruses.

Next they want to broaden the study more to include people with a wider range of ancestry.

It doesn’t come close to explaining all asymptomatic cases, and they didn’t look at how it might stack with immune responses that are actually targeted at covid (vaccines, prior infections), or whether it also reduces the chances of long-term damage from covid.

But wouldn’t it be great if someone could come up with a supplement based on what this HLA variant produces that’ll cause your immune system to generalize better? Even if it’s just within coronaviruses?

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For the second day in a row we’ve gotten a notice of a Covid exposure in the kid’s classroom. One more case and it’s technically an outbreak.

Mask-optional was one thing when cases were low and flat, but the numbers have been climbing for weeks. And that’s not including however many at-home tests don’t get reported. The classroom is now mask-required for the next 10 days, which means the rest of the school year.

Fortunately the kid’s been wearing N95s since before the first exposure!

I looked up the county regs for what to do after a third case. They’re wonderfully vague: “If a DPH outbreak investigation is activated, a public health investigator will contact the school to coordinate the outbreak investigation.”

Well, it’s going to put a damper on end-of year parties, even if it stops here.

Update June 10: They managed to get through the rest of the school year without another Covid case!

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Love how the same people who are all “COVID isn’t a problem” are also dead set on keeping certain people out of the country just in case they might bring COVID in.

No wonder they distrust actual public health measures and think the government is just using COVID as an excuse for…something. Because that’s what they would do. That’s what they have done.

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Google wished me a happy second coronaversary this morning.

Google Photos notification with 2 years ago, today, March 8, 2020, and a picture of a curving coastline

Well, not in so many words. But I count March 8, 2020 as my last normal day, the day I went out to de-stress by taking pictures of the ocean, seagulls, and a zillion tiny clams, grabbed coffee at Peet’s on the way home, and came down with the flu that afternoon. By the time I recovered a few days later, everything had shut down.

I never did get back to the office. I’m still at the same company, but they let the lease expire, tossed everything in storage, and set up a new, smaller office for people to come back to when things settled out.

I finally got to see the new office last month. And see some of my co-workers in person. And pick up the stuff I’d left on my desk, like a coffee mug that I would have washed on Monday morning if I hadn’t been sick.

It’s weird how it feels both longer and shorter than 2 years. Everything kind of blurs together. And yet it’s so different now from the start of the pandemic.

We’re not locked down. Just about everything that’s still in business is open, with precautions. Schools and playgrounds and parks are open. COVID tests are little boxes you buy at the pharmacy and use at home instead of driving through an improvised clean room for someone in a hazmat suit to stick a pole through the window.

It’s not “normal,” but it’s a lot closer to the old normal than those first months were.

The virus is still out there, but we understand better how it spreads and how to treat it, and vaccines make it a lot less likely to be severe for those who’ve gotten them.

(If only more people actually trusted the people who know what they’re talking about, rather than the ones telling them what they want to hear.)

On the down side, lots of people are still getting sick and dying, prices are up, the global supply chain hasn’t recovered, cynical politicians have taken advantage of the pandemic to further divide society and cement their hold on people who just want to be told what they want to hear instead of what they need to know, and a large nuclear power has decided now is an excellent time to invade their neighbors and possibly spark a bigger conflagration.

Things are still in flux. Which is probably part of why it’s still blurring together. We’ve still got problems to fix (or mitigate) at every level from home to global. Whatever the new normal is going to be, we haven’t made it yet.

But not having a direction, not having milestones, not having a sense what the landscape is going to be, makes it hard to see accomplishments, hard to be motivated. It’s been a draining two years. And even though a lot of things are better, other things are worse, and it’s still so damn draining. I’m exhausted, my wife’s exhausted, our kid’s switched school situations so many times he barely participates anymore.

I want a new normal. A better normal. But the last few years have also made it abundantly clear that more people than I thought don’t want to make things better, they just want other people to have it worse than them.

And yet I know so many people do have it worse than me. I have a job I can do from home. Even in the lockdown, I was quarantined with my family, not alone. I live in an area with enough open space that even during the heaviest restrictions I could still go out for a walk. My immediate family hasn’t caught COVID, and the extended family members who did recovered from it. And of course I’m not dodging mortar shells or fleeing a battle zone. So what am I complaining about? By some standards my life is charmed, so what business do I have feeling depressed and anxious?

Brains are weird. You spend a little time in fight/flight/freeze mode and you’re able to stop or dodge danger. You spend a lot of time in it and your brain just stops classifying input properly.