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Dr. Edward Clariss synthesized a speed formula from the very chemicals that gave the Flash his speed.
Eobard Thawne used 25th-Century science to duplicate the Flash’s speed, then travelled back in time to meet his idol, only to discover that he was destined to be the Flash’s greatest enemy. He then set out to prove it right.
Driven mad by helplessness and granted time-based powers mimicking super-speed, Hunter Zolomon dedicated his life to becoming the Flash’s opposite.
A product of the Soviet superspeed program Blue Trinity, Christina became a disciple of Savitar until he threatened to replace her with Jesse.
Cloned from Bart Allen, spliced with Thawne DNA, Inertia was to become the ultimate triumph of the Thawnes over the Allens by replacing Impulse.

The Flash Companion The Flash Companion
Preview at Speed Force
Order at TwoMorrows